Classic Moyamoya Disease is a progressive cerebrovascular disorder that primarily affects the blood vessels in the brain. It is characterized by the narrowing or blockage of the major blood vessels at the base of the brain, leading to reduced blood flow and subsequent formation of collateral blood vessels in an attempt to compensate. This condition predominantly affects the internal carotid arteries, which are responsible for supplying blood to the brain.
The term "classic" refers to the most common form of Moyamoya Disease, which typically occurs in children and young adults. The exact cause of this disease is unknown, but it is believed to have a genetic component, with some cases being familial. Classic Moyamoya Disease is more prevalent in individuals of Asian descent, particularly Japanese.
Symptoms of classic Moyamoya Disease can vary widely but often include recurrent transient ischemic attacks (TIAs) or strokes, characterized by the sudden onset of neurological deficits such as weakness, numbness, or speech difficulties. Seizures, headaches, and cognitive impairment may also occur. The progressive nature of this condition means that symptoms tend to worsen over time.
Diagnosis of classic Moyamoya Disease typically involves a combination of medical history evaluation, physical examination, and neuroimaging studies such as magnetic resonance imaging (MRI) or computed tomography angiography (CTA). Treatment options include surgical revascularization procedures to restore blood flow to the brain, as well as supportive therapies to manage symptoms and reduce the risk of stroke.
In summary, classic Moyamoya Disease is a cerebrovascular disorder characterized by the narrowing of major blood vessels in the brain, leading to reduced blood flow and the formation of collateral blood vessels. It primarily affects children and young adults, often causing recurrent TIAs or strokes. The diagnosis is based on medical history
