GAMMA DELTA T CELL RECEPTOR Meaning and
Definition
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A gamma delta T cell receptor refers to a type of antigen receptor found on the surface of gamma delta T cells, a subset of T lymphocytes involved in the immune response. The gamma delta T cell receptor is a heterodimeric protein that consists of two chains – a gamma chain and a delta chain – connected by disulfide bonds.
The gamma delta T cell receptor plays a pivotal role in recognizing and binding to specific antigens, such as peptides or lipid molecules, presented by major histocompatibility complex (MHC) proteins on the surface of target cells. This interaction is important for the activation and subsequent response of gamma delta T cells. Unlike conventional alpha beta T cells, which primarily recognize protein antigens, gamma delta T cells are known to exhibit a broader reactivity towards both self and non-self antigens, thereby bridging the innate and adaptive immune responses.
The gamma delta T cell receptor exhibits a distinct and less diverse repertoire compared to alpha beta T cell receptors. This restricted diversity arises from limited gene rearrangement during the development of gamma delta T cells in the thymus. Despite its limited diversity, the gamma delta T cell receptor contributes to immune surveillance in various tissues, particularly mucosal surfaces and epithelial barriers. It plays a vital role in immune responses against pathogens, tumor cells, and autoimmune reactions, highlighting its significance in immunity and potential therapeutic applications.
Common Misspellings for GAMMA DELTA T CELL RECEPTOR
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