HYDROXYMETHYLBILANE SYNTHETASE Meaning and
Definition
-
Hydroxymethylbilane Synthetase, also known as HMB synthetase or porphobilinogen synthase, is an essential enzyme involved in the synthesis of heme, a vital component of several important proteins in the body. HMB synthetase is the third enzyme in the heme biosynthetic pathway.
The hydroxymethylbilane synthetase enzyme facilitates the formation of hydroxymethylbilane from four molecules of porphobilinogen. This reaction occurs through a series of steps, including condensation, dehydration, and cyclization processes. These steps are necessary to form the hydroxymethylbilane molecule, which is further metabolized to form heme.
HMB synthetase is primarily found in the liver, where the majority of heme synthesis takes place. However, it is also present in other tissues to some extent. This enzyme is regulated by various factors, including heme concentration and other intermediates in the heme biosynthetic pathway.
Mutations in the gene encoding HMB synthetase can lead to a rare genetic disorder called acute intermittent porphyria (AIP). AIP is characterized by a deficiency in HMB synthetase activity, resulting in the accumulation of porphobilinogen and other precursors in the body. This can lead to various symptoms, such as abdominal pain, neuropsychiatric disturbances, and potential life-threatening acute attacks.
In summary, hydroxymethylbilane synthetase is a crucial enzyme involved in the synthesis of heme. Its activity is essential for maintaining the proper production of heme, which is required for various biological processes and deficiency or mutations in this enzyme can lead to the development of a rare disorder called acute intermittent porphyria.
Common Misspellings for HYDROXYMETHYLBILANE SYNTHETASE
- gydroxymethylbilane synthetase
- bydroxymethylbilane synthetase
- nydroxymethylbilane synthetase
- jydroxymethylbilane synthetase
- uydroxymethylbilane synthetase
- yydroxymethylbilane synthetase
- htdroxymethylbilane synthetase
- hgdroxymethylbilane synthetase
- hhdroxymethylbilane synthetase
- hudroxymethylbilane synthetase
- h7droxymethylbilane synthetase
- h6droxymethylbilane synthetase
- hysroxymethylbilane synthetase
- hyxroxymethylbilane synthetase
- hycroxymethylbilane synthetase
- hyfroxymethylbilane synthetase
- hyrroxymethylbilane synthetase
- hyeroxymethylbilane synthetase
- hydeoxymethylbilane synthetase
- hyddoxymethylbilane synthetase
Etymology of HYDROXYMETHYLBILANE SYNTHETASE
The word "Hydroxymethylbilane Synthetase" has a Greek and Latin etymology.
1. Hydroxymethyl:
- "Hydro-" is derived from the Greek word "hudro", meaning water.
- "Methyl" is derived from the Greek word "methy", which means sweetness or sweet wine.
2. Bilane:
- "Bilane" is a suffix derived from the Latin word "bilis", which means bitter bile or gall.
3. Synthetase:
- "Synthetase" is a suffix derived from the Greek word "sunthesis", which means putting together or combination.
Therefore, the etymology can be broken down as follows:
Hydroxymethyl = sweet water
Bilane = bitter bile
Synthetase = putting together or combination.
