Mouse Encephalomyelitis Virus (MEV) is a neurotropic virus that primarily affects mice and belongs to the family Picornaviridae. It is classified within the genus Enterovirus. Encephalomyelitis refers to inflammation of both the brain (encephalo-) and spinal cord (myelitis).
MEV is known to cause an infectious disease called mouse encephalomyelitis, which manifests as a severe neurological disorder. The virus primarily targets the central nervous system, resulting in neuroinflammation and damage to the brain and spinal cord tissues.
Transmission of MEV occurs through direct contact with infected animals, typically via respiratory secretions or feces. In addition to mice, several other rodent species can serve as carriers and transmitters of the virus.
Symptoms of mouse encephalomyelitis may include hindlimb paralysis, tremors, hunched posture, ataxia, and seizures. Additionally, infected mice may show signs of weight loss, decreased activity, and neurological deficits. The severity of the disease can vary, ranging from mild to fatal, depending on the strain of MEV and the susceptibility of the host.
Research on mouse encephalomyelitis and MEV has contributed to the understanding of viral neuroinfections and has implications for both veterinary and human medicine. The study of MEV in mice has served as a valuable animal model for investigating viral-induced neurologic diseases and testing potential therapeutic interventions.
