REELER MOUSE Meaning and
Definition
-
Reeler Mouse
Definition:
A reeler mouse refers to a genetically modified laboratory mouse strain that displays distinct neurological abnormalities, particularly in its motor coordination and cognitive functioning. The name originates from the characteristic phenotype presented by these mice, where they exhibit a unique reeling gait while moving, hence the term "reeler." The reeler mouse strain is commonly used in neuroscience research to study various aspects of brain development, neuronal migration, and the functioning of specific brain regions.
The distinct phenotype of reeler mice arises due to a spontaneous mutation in a specific gene called reelin. This gene is responsible for providing guidance cues to developing neurons during the embryonic stage, ensuring proper migration and layering in the cerebral cortex and cerebellum. In reeler mice, the mutation in the reelin gene disrupts the normal development of these brain regions, resulting in disorganization and misalignment of neurons. This, in turn, leads to impaired motor coordination and balance, along with cognitive deficits.
Reeler mice have proven to be invaluable tools in neurobiology research, aiding scientists in unraveling the mechanisms underlying neuronal migration, synaptic plasticity, and the role of specific brain circuits in controlling motor function and cognitive processes. By studying the reeler mouse strain, researchers aim to gain insights into the genetic and molecular factors that govern normal brain development, as well as to develop potential therapeutic interventions for certain neurological disorders associated with neuronal migration disorders, such as lissencephaly or cerebellar hypoplasia.
Common Misspellings for REELER MOUSE
- eeeler mouse
- deeler mouse
- feeler mouse
- teeler mouse
- 5eeler mouse
- 4eeler mouse
- rweler mouse
- rseler mouse
- rdeler mouse
- rreler mouse
- r4eler mouse
- r3eler mouse
- rewler mouse
- resler mouse
- redler mouse
- rerler mouse
- re4ler mouse
- re3ler mouse
- reeker mouse
- reeper mouse
Infographic
Add the infographic to your website:
