SEVENLESS PROTEIN SON Meaning and
Definition
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The "Sevenless Protein Son" refers to a particular molecular signaling pathway that plays a vital role in the development of the compound eye in the fruit fly Drosophila melanogaster. This pathway is named after two key components involved: the "Sevenless Protein" and the "Son of Sevenless" protein.
The Sevenless Protein is a transmembrane receptor tyrosine kinase that is expressed on the surface of the photoreceptor cell R7 in the fruit fly's eye. It receives extracellular cues from the surrounding cells and initiates a signaling cascade within the cell upon activation. The activation of the Sevenless Protein triggers the recruitment and activation of intracellular signaling proteins, eventually leading to the specification and differentiation of the R7 cell.
The Son of Sevenless (Sos) protein is an important cytoplasmic mediator in this pathway. Once the Sevenless Protein is activated, it recruits the Sos protein to the cell membrane, where Sos acts as a guanine nucleotide exchange factor (GEF) for a small GTPase called Ras. This exchange of nucleotides activates Ras, initiating a downstream cascade of protein phosphorylation events that ultimately result in the cellular responses necessary for proper eye development.
The Sevenless Protein Son pathway is crucial for establishing the precise arrangement of photoreceptor cells in the Drosophila eye. Defects in this pathway can lead to the loss or misplacement of specific photoreceptor cells, ultimately disrupting vision. Hence, understanding the mechanisms and functions of the Sevenless Protein Son pathway contributes to our knowledge of eye development and the molecular basis of certain visual disorders.
Common Misspellings for SEVENLESS PROTEIN SON
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